Use of Nonsteroidal Anti-inflammatory Drugs in Orthodontics: Literature review
DOI:
https://doi.org/10.15332/us.v17i0.2187Keywords:
Orthodontic pain, dental movement, orthodontics, inflammation, NSAIDsAbstract
90% of patients with orthodontic treatment report postoperative pain to the application of mechanical forces, reaching maximum discomfort at 24 hours. Studies suggest the use of non-steroidal anti-inflammatory analgesics (NSAIDs) for the control and management of pain as the method of choice. The aim of the present review was to evaluate existing literature on NSAIDs used in patients undergoing orthodontic treatment and its relationship with the inflammatory process, review pharmacological alternatives and suggest the most appropriate medication for the management and control of pain. In order to carry out this study, databases such as Pubmed, Scielo, ScienceDirect, EBSCOhost, and Google Academic were used, having as search limits documents published between 2006 and 2018, with the exception of two studies, one from 1996 and the other from 2000, which provided information of great relevance. Articles were considered as systematic reviews, prospective and retrospective studies. It was concluded that it is important to manage the pain involved in orthodontic treatments without interfering with the inflammatory process that accompanies it. When analyzing different NSAIDs, no significant differences were observed in terms of pain reduction, with the exception of Paracetamol, which is considered the most appropriate, because it concentrates its action at the CNS level, not altering the synthesis of Prostaglandins and allowing the dental movement. It is suggested that studies be conducted on drugs such as Indomethacin, Diclofenac, Flurbiprofen and Etoricoxib, due to the lack of evidence in this regard.
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References
Salmassian R, Oesterle LJ, Shellhart WC, Newman SM. Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement. Am J Orthod Dentofac Orthop. 2009;135(4):516-21 [Internet]. American Association of Orthodontists. DOI:10.1016/j.ajodo.2007.05.020.
Peña-Montero CA, Rojas-García AR, Gutiérrez-Rojo JF. Mediadores químicos y el efecto de los analgésicos en el tratamiento de ortodoncia. 2012;1(2):55-61.
Patel S, Mcgorray SP, Yezierski R, Fillingim R, Logan H, Wheeler TT. Effects of analgesics on orthodontic pain. Am J Orthod Dentofac Orthop. 2011;139(1):e53-8. [Internet]. American Association of Orthodontists. DOI:10.1016/j.ajodo.2010.07.017.
Polat Ö. Pain and Discomfort After Orthodontic Appointments. Semin Orthod. 2007;13(4):292-300. DOI:10.1053/j.sodo.2007.08.010
Zambrano D, Zamarripa E, Parra R. Acetaminofén con codeína eficiente contra el dolor dentario. Ciencia UAT. 2008;3(2):48-51.
Ellison DL. Physiology of Pain. Crit Care Nurs Clin NA. 2017;29(4):397-406. [Internet]. Elsevier Inc; DOI:10.1016/j.cnc.2017.08.001.
Saquelli A, Orellana A, Garzón R. Alternativas de tratamiento para disminuir el dolor de origen ortodóncico. Rev Latinoam Ortod y Odontopediatría. 2010; Disponible en: https://www.ortodoncia.ws/publicaciones/2010/art-6/.
Najafi HZ, Oshagh M, Salehi P, Babanouri N, Torkan S. Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial. Prog Orthod. 2015;16(34):3-9. [Internet]. Progress in Orthodontics. DOI:10.1186/s40510-015-0104-y.
Sandhu SS, Cheema MS, Khehra HS. Comparative effectiveness of pharmacologic and nonpharmacologic interventions for orthodontic pain relief at peak pain intensity: A Bayesian network meta-analysis. Am J Orthod Dentofac Orthop. 2014;150(1):13-32. [Internet]. American Association of Orthodontists. DOI:10.1016/j.
ajodo.2015.12.025.
Ashley PF, Parekh S, Moles DR, Anand P, MacDonald LC. Preoperative analgesics for additional pain relief in children and adolescents having dental treatment. Cochrane Database Syst Rev. 2016(8):Cd008392. DOI:10.1002/14651858.CD008392.pub3.
Bird S, Williams K, Kula K. Preoperative acetaminophen vs ibuprofen for control of pain after orthodontic separator placement. Am J Orthod Dentofac Orthop. 2007;132(4):504-10. DOI:10.1016/j.ajodo.2006.11.019.
Xiaotinga L, Yin T, Yangxi C. Interventions for pain during fixed orthodontic appliance therapy. Angle Orthod. 2010;80(5):925-32. DOI:10.2319/010410-10.1.
Arias O, Márquez-Orozco MC. Aspirin, acetaminophen, and ibuprofen: Their effects on orthodontic tooth movement. Am J Orthod Dentofac Orthop. 2006;130(3):364-70. DOI:10.1016/j.ajodo.2004.12.027.
Vargas P, Piñeiro M, Palomino H, Torres-Quintana M. Factores modificantes del movimiento dentario ortodóncico. Av Odontoestomatol. 2010;26(1):45-53.
Krishnan V, Davidovitch Z. The effect of drugs on orthodontic tooth movement. Orthod Craniofac Res. 2006;9:163-71. DOI:10.1111/j.1601-6343.2006.00372.x.
Primo J. Niveles de evidencia y grados de recomendación (I/II). Enferm Inflamatoria Intest al día. 2003;2:2001-4.
Kyrkanides S, O’Banion MK, Subtelny JD. Nonsteroidal anti-inflammatory drugs in orthodontic tooth movement: Metalloproteinase activity and collagen synthesis by endothelial cells. Am J Orthod Dentofac Orthop. 2000;118(2):203-9. DOI:10.1067/mod.2000.105872
Fernández Duharte J, Zapata Blanco E, Santiesteban Sauqué X, Lescay Bell O, Rosell Torres L. Uso y abuso de las prostaglandinas. MEDISAN. 19(1):113-121. [Internet]. 2015 Ene [citado 2018 Ene 15]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192015000100015&lng=es.
Gálvez Lima Á. Efecto antiinflamatorios de los ácidos grasos omega - 3. Scientifica. 2007 Sep. 5(5):43-49. [revista en la Internet]. [citado 2018 Ene 15]. Disponible en: http://www.revistasbolivianas.org.bo/scielo.php?script=sci_arttext&pid=S1813-00542007000200010&lng=es.
García JA, Gómez-Reino J. Fisiopatología de la ciclooxigenasa-
y ciclooxigenasa-2. Rev Española de Reumatología. 2000;27:33-5.
Vaquero P, B P, E L, Santiago A GF. Reabsorción radicular durante el tratamiento ortodóncico: causas y recomendaciones de actuación. Cient Dent. 2011;8(1):61-70.
Bradley RL, Ellis PE, Thomas P, Bellis H, Ireland AJ, Sandy JR. A randomized clinical trial comparing the efficacy of ibuprofen and paracetamol in the control of orthodontic pain. Am J Orthod Dentofac Orthop. 2007;132(4):511-7. DOI:10.1016/j.ajodo.2006.12.009
Batlouni M. Antiinflamatorios no esteroides: efectos cardiovasculares, cerebrovasculares y renales. Arq. Bras. Cardiol. 2010 Apr;94(4):556-563. [Internet]. [cited 2017 Dec 26]. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2010000400019&lng=
en.
Behal N, Singh Kanwar S, Sharma P, Sanyal SN. Effect of non-steroidal anti-inflammatory drug etoricoxib on the hematological parameters and enzymes of colon and kidney. Nutr. Hosp. 2009 Jun;24(3):326-332 [Internet]. [citado 2018 Ene 30]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112009000300010&lng=es.
Bartzela, T. Turp, J. Motschall, E. Maltha, J. Medication effects on the rate of orthodontic tooth movement: A systematic literature review. American Journal of Orthodontics. 2009. DOI:10.1016/j.ajodo.2008.08.016.
Polat O, Karaman A. Pain Control During Fixed Orthodontic Appliance Therapy. Angle Orthod. 2005;75:210-215. DOI:10.1043/0003-3219(2005)075<0210:PCDFOA>2.0.CO;2.
Kehoe MJ, Cohoen SM, Zarrinia K, Cowan A. The effect of acetaminophen, ibuprofen and misoprostolonprostaglandin E2 synthesis and the degree and rate of orthodontic tooth movement. Angle Orthod. 1996;66:339-50. DOI:10.1043/0003-3219(1996)066<0339:TEOAIA>2.3.CO;2.
Angelopoulou MV, Vlachou V, Halazonetis DJ. Pharmacological management of pain during orthodontic treatment: A meta-analysis. Orthod. Craniofac. Res. 2012;15(2):71-83. DOI:10.1111/j.1601-6343.2012.01542.x.
Krasny M, Zadurska M, Cessak G, Fiedor P. Analysis of effect of NSAID’s drugs on teeth and oral tissues during orthodontic treatment. Report based on literature. Acta Pol. Pharm. 2013;70(3):573-577.
Possi A, Gallelli L. Pain management for dentists: The role of Ibuprofen. Annali di Stomatologia. 2011;11(Supply 3-4):3-24.
