Deep brain stimulation modeling for several anatomical and electrical considerations

Autores/as

  • Cristian Alejandro Torres-Valencia M.Sc. Universidad Tecnológica de Pereira Pereira,
  • Genaro Daza-Santacoloma Ph.D Instituto de Epilepsia y Parkinson del Eje Cafetero – NEUROCENTRO Pereira,
  • Mauricio Alexander Álvarez-López Ph.D Universidad Tecnológica de Pereira Pereira,
  • Álvaro Ángel Orozco-Gutiérrez Ph.D Universidad Tecnológica de Pereira Pereira,

DOI:

https://doi.org/10.15332/iteckne.v11i2.723

Palabras clave:

Deep Brain Stimulation, electric propagation, finite element method, Laplace equation, Parkinson disease, Poisson equation, subthalamic nucleus

Resumen

Deep Brain Stimulation (DBS) is a clinical treatment for Parkinson disease symptoms. DBS consists in the implantation of a stimulation electrode into the Subthalamic nucleus (STN) for the excitation of specific regions inside the STN. The stimulation potential has a few parameters that should be adjusted in order to achieve the desired treatment effect. The adjust is performed by the neurologist in several sessions with the patients and is not an exact procedure. In recent years there have been several works on the construction of propagation models of DBS, including head geometries and medium properties in order to visualize the possible effects of DBS while the stimulation parameters are adjusted. This work presents the construction of propagation models using the Finite Element Method (FEM) for the solution of Laplace or Poisson equations that govern the propagation phenomena. By the construction of these models, the shape and magnitude of the electric propagation inside the objective structures can be obtained.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

P. Limousin, P. Pollak, A. Benazzouz, D. Hoffmann, J. F. Le Bas, E. Broussolle, J. E. Perret, and A. L. Benabid, “Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation.” Lancet, vol. 345, no. 8942, pp. 91–95, 1995.

Benabid, A. L. Deep brain stimulation for Parkinson’s disease. Current Opinion in Neurobiology, no, 13, pp. 696-706, 2003.

Tarparelli, R.; Iovine, R.; La Spada, L.; Vegni, L., “Electromagnetic analysis of deep brain stimulation,” Electromagnetics in Advanced Applications (ICEAA), International Conference, pp.1153-1155, 9-13, 2013.

G. Walckiers, B. Fuchs, J.-P. Thiran, J. R. Mosig, and C. Pollo, “Influence of the implanted pulse generator as reference electrode in finite element model of monopolar deep brain stimulation,” Journal of Neuroscience Methods, vol. 186, pp. 90–96, 2010.

C. C. McIntyre and W. M. Grill, “Extracellular stimulation of central neurons: Influence of stimulus waveform and frequency on neuronal output,” Journal of Neurophysiology, vol. 88, 2002, pp. 1592–1604.

A.L. Benabid, S. Chabardes, J. Mitrofanis, P. Pollak, “Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease”, Lancet Neurol, vol. 8, no.1, 2009, pp.67-81.

C. C. McIntyre, S. Morib, D. L. Shermanc, N. V. Thakorc, and J. L. Vitek, “Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus,” Clinical neurophysiology, vol. 115, pp. 589–595, 2004.

P. F. Grant and M. M. Lowery, “Electric field distribution in a finite-volume head model of deep brain stimulation,” Medical engineering & physics, vol. 31, pp. 1095–1103, 2009.

M. Liberti, F. Apollonio, A. Paffi, M. Parazzini, F. Maggio, T. Novellino, P. Ravazzani, and G. D’Inzeo, “Fundamental electrical quantities in deep brain stimulation: Influence of domain dimensions and boundary conditions.” Lyon, France: 29th annual international conference of the IEEE EMBS, pp. 6668–6671, 2007.

M. N. O. Sadiku, “Elements of electromagnetics.” USA: Oxford University Press, 2002.

G. Walckiers, “Bio-electromagnetic model of deep brain stimulation.” IEL, 2009.

D. Hutton. “Fundamentals of Finite Element Analysis,” United States: McGraw-Hill, 2004.

C. Butson, S. E. Cooper, J. M. Henderson and C. C. McIntyre, “Patient-specific analysis of the volume of tissue activated during deep brain stimulation”, NeuroImage, 2007.

L.J. Segerind, “Applied Finite Element Analysis”, New York: JohnWiley & Sons, 1984.

J. W. Kim and P. A. Robinson, “Compact dynamical model of brain activity”, American Physical Society, Phys. Rev. E. 031907, Vol. 75, i. 3, p. 031907-031917 , 2007.

A. Chaturvedi, C. R. Butson, F. Scott, F. Lempka, E. Cooper, and C. Cameron, “Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictions. Brain Stimulation”, vol.3, no. 2, pp. 65–77, 2010.

Descargas

Publicado

2014-12-31

Cómo citar

Torres-Valencia, C. A., Daza-Santacoloma, G., Álvarez-López, M. A., & Orozco-Gutiérrez, Álvaro Ángel. (2014). Deep brain stimulation modeling for several anatomical and electrical considerations. ITECKNE, 11(2), 140–148. https://doi.org/10.15332/iteckne.v11i2.723

Número

Sección

Artículos de Investigación e Innovación