Diseño de un prototipo de máquina para hipotermia cerebral en neonatos
Keywords:
Hypoxic isquemic encephalopathy, Hypothermia, Heat transfer
Abstract
The Mechatronics Engineering Faculty at Universidad Santo Tomas in Bucaramanga, initiated in 2005 the process of formulation and development of a work whose idea was conceived by the Clinica Materno Infantil San Luis in Bucaramanga, about building an equipment to apply cerebral hypothermia in neonates, in order to prevent complications due to hypoxic ischemic encephalopathy (HIE), since this if one of the leading causes of neurological diseases in neonates. This paper describes the design and building of the initial prototype of a machine with a cooling system based on solid state Peltier cells. This machine produces hypothermia on the brain in neonates. The development of a second prototype based on the improvements made to the first in various aspects of its structure is also described. The second prototype is a machine that applies a proper and stable cooling temperature on the brain of neonates, during the time specified by the medical specialists
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References
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[4] A. Gunn, P. Gluckman, T. Gunn, Selective head cooling in newborn infants after perinatal asphyxia: a safety study, Pediatrics, 1998, 102, pp 885-892
[5] S. Shankaran, A. Laptook, L. Wright, et al, Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants, Pediatrics, 2002, 110, pp. 377-385
[6] K. Haaland, E. Loberg, P. Steen, M. Thoresen, Posthypoxic hypothermia in newborn piglets, Pediatr Res, 1997, 41, pp. 505-512
[7] M. Thoresen, R. Bagenholm, E. Loberg, F. Apricena, I. Kjelmer, Posthypoxic cooling of neonatal rats provides protection against brain injury, Arch Dis Child Fetal Neonatal, 1996, 74, F3-F9
[8] M. Thoresen, J. Penrice, A. Lorek, et al, Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res, 1995, 37, pp 667-670
[9] E. Sirimanne, R. Blumberg, D. Bossano, et al, The effect of prolonged modification of cerebral temperature on outcome following hypoxic isquemic injury in the infant rat, Pediatr Res, 1996, 39, pp 591-598
[10] P. Gluckman, J.S. Wyatt, D. Azzopardi, R. Ballard, A.D. Edwards, D.M. Ferriero, R.A. Polin, C. Robertson, M. Thoresen, A. Whitelaw, A.J. Gunn. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial. Lancet, 2005, Vol. 365, pp 663-670
[11] M. Rutherford, D. Azzopardi, A. Whitelaw, F. Cowan, S. Renowden, A.D. Edwards, M. Thoresen, Mild Hypothermia and the Distribution of Cerebral Lesions in Neonates With Hypoxic-Ischemic Encephalopathy. Pediatrics, 2005, 116(4), pp 1001-1006
[12] M.R. Battin, J.A. Dezoete, T.R. Gunn, P. Gluckman, A.J. Gunn. Neurodevelop-mental Outcome of Infants Treated With Head Cooling and Mild Hypothermia After Perinatal Asphyxia. Pediatrics, 2001, 107(3), pp 480-484
[13] M.R. Battin, J. Penrice, T.R. Gunn, A.J. Gunn. Treatment of Term Infants With Head Cooling and Mild Systemic Hypothermia (35.0 Degrees C and 34.5 Degrees C) After Perinatal Asphyxia. Pediatrics, 2003, 111(2), pp 244-251
[14] Z.L. Lin, H.M. Yu, J. Lin, S.Q. Chen, Z.Q. Liang, Z.Y. Zhang. Mild Hypothermia Via Selective Head Cooling As Neuroprotective Therapy in Term Neonates With Perinatal Asphyxia: an Experience From a Single Neonatal Intensive Care Unit. Journal of Perinatology, 2006, 26(3), pp 180-184
[15] G. Simbruner, C. Haberl, V. Harrison, L. Linley, A.E. Willeitner. Induced Brain Hypothermia in Asphyxiated Human Newborn Infants: a Retrospective Chart Analysis of Physiological and Adverse Effects. Intensive Care Medicine, 1999, 25(10), pp 1111-1117
[16] W.H. Zhou, X.M. Shao, Y. Cao, C. Chen, X.D. Zhang. Safety Study of Hypothermia for Treatment of HypoxicIschemic Brain Damage in Term Neonates. Acta Pharmacologica Sinica, 2002, 23, pp 64-68
[17] C. Prada, J. Duarte, W. Castro, Diseño de un equipo para generación de hipotermia artificial en el cerebro de los neonatos, Proyecto de grado Ingeniería Mecatrónica, Universidad Santo Tomás, Bucaramanga, 2006
[18] A. C. Guyton, Tratado de fisiología médica, 5ª ed., Editorial Interamericana, Méjico, 1977
[19] J. Millán. (2006, Febrero 14). Peltier. [Online]. Disponible: http://www.sc.ehu.es/nmwmigaj/PELTIER.htm#t
[2] A. Legido, C. Katsetos, O. Mishra, M. Delivoria-Papadopoulos. (2006, Febrero). Perinatal Hypoxic Ischemic Encephalopathy: Current and Future Treatments. International Pediatrics. [Online]. 15(3). pp 143-151
[3] J. Martínez, M. Torres, S. Jimeno, R. Escrig, P. Sáenz, I. Izquierdo, Prevención del daño cerebral hipóxicoisquémico neonatal: viejos problemas, nuevas esperanzas, Revista Mexicana de Pediatría, Vol. 73, No. 4, Jul-Ago 2006, pp. 184-191
[4] A. Gunn, P. Gluckman, T. Gunn, Selective head cooling in newborn infants after perinatal asphyxia: a safety study, Pediatrics, 1998, 102, pp 885-892
[5] S. Shankaran, A. Laptook, L. Wright, et al, Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants, Pediatrics, 2002, 110, pp. 377-385
[6] K. Haaland, E. Loberg, P. Steen, M. Thoresen, Posthypoxic hypothermia in newborn piglets, Pediatr Res, 1997, 41, pp. 505-512
[7] M. Thoresen, R. Bagenholm, E. Loberg, F. Apricena, I. Kjelmer, Posthypoxic cooling of neonatal rats provides protection against brain injury, Arch Dis Child Fetal Neonatal, 1996, 74, F3-F9
[8] M. Thoresen, J. Penrice, A. Lorek, et al, Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res, 1995, 37, pp 667-670
[9] E. Sirimanne, R. Blumberg, D. Bossano, et al, The effect of prolonged modification of cerebral temperature on outcome following hypoxic isquemic injury in the infant rat, Pediatr Res, 1996, 39, pp 591-598
[10] P. Gluckman, J.S. Wyatt, D. Azzopardi, R. Ballard, A.D. Edwards, D.M. Ferriero, R.A. Polin, C. Robertson, M. Thoresen, A. Whitelaw, A.J. Gunn. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial. Lancet, 2005, Vol. 365, pp 663-670
[11] M. Rutherford, D. Azzopardi, A. Whitelaw, F. Cowan, S. Renowden, A.D. Edwards, M. Thoresen, Mild Hypothermia and the Distribution of Cerebral Lesions in Neonates With Hypoxic-Ischemic Encephalopathy. Pediatrics, 2005, 116(4), pp 1001-1006
[12] M.R. Battin, J.A. Dezoete, T.R. Gunn, P. Gluckman, A.J. Gunn. Neurodevelop-mental Outcome of Infants Treated With Head Cooling and Mild Hypothermia After Perinatal Asphyxia. Pediatrics, 2001, 107(3), pp 480-484
[13] M.R. Battin, J. Penrice, T.R. Gunn, A.J. Gunn. Treatment of Term Infants With Head Cooling and Mild Systemic Hypothermia (35.0 Degrees C and 34.5 Degrees C) After Perinatal Asphyxia. Pediatrics, 2003, 111(2), pp 244-251
[14] Z.L. Lin, H.M. Yu, J. Lin, S.Q. Chen, Z.Q. Liang, Z.Y. Zhang. Mild Hypothermia Via Selective Head Cooling As Neuroprotective Therapy in Term Neonates With Perinatal Asphyxia: an Experience From a Single Neonatal Intensive Care Unit. Journal of Perinatology, 2006, 26(3), pp 180-184
[15] G. Simbruner, C. Haberl, V. Harrison, L. Linley, A.E. Willeitner. Induced Brain Hypothermia in Asphyxiated Human Newborn Infants: a Retrospective Chart Analysis of Physiological and Adverse Effects. Intensive Care Medicine, 1999, 25(10), pp 1111-1117
[16] W.H. Zhou, X.M. Shao, Y. Cao, C. Chen, X.D. Zhang. Safety Study of Hypothermia for Treatment of HypoxicIschemic Brain Damage in Term Neonates. Acta Pharmacologica Sinica, 2002, 23, pp 64-68
[17] C. Prada, J. Duarte, W. Castro, Diseño de un equipo para generación de hipotermia artificial en el cerebro de los neonatos, Proyecto de grado Ingeniería Mecatrónica, Universidad Santo Tomás, Bucaramanga, 2006
[18] A. C. Guyton, Tratado de fisiología médica, 5ª ed., Editorial Interamericana, Méjico, 1977
[19] J. Millán. (2006, Febrero 14). Peltier. [Online]. Disponible: http://www.sc.ehu.es/nmwmigaj/PELTIER.htm#t
Published
2013-11-19
How to Cite
Castro Jaluba, W., Rincón Osorio, F., López Figueroa, A., Obando Correa, Óscar, Rosales Acevedo, R., & García Harcker, J. (2013). Diseño de un prototipo de máquina para hipotermia cerebral en neonatos. ITECKNE, 7(1), 5-12. https://doi.org/https://doi.org/10.15332/iteckne.v7i1.2703
Issue
Section
Research and Innovation Articles
