Controlled release of Metoprolol Succinate from the organo-mineral complex Metoprolol Succinate-Montmorillonite

Keywords: Metoprolol Succinate, Controlled release system, Aluminosilicates, Kinetic models, Montmorillonite


Due to the current need to prolong the action of a drug and reduce the side effects that can be generated in the patient, a large number of scientific investigations have been developed that focus on the implementation of systems that cover the needs set out above, giving origin thus to controlled release systems.

Therefore, the synthesis of the Metoprolol Succinate (MPS) -montmorillonite (MMT) complex was carried out at pH 8, where the presence of the drug in the interlaminar space of the aluminosilicate was determined by XRD of polycrystalline samples, and different complementary analytical techniques (Uv- Vis, FTIR and SEM), obtaining as a result that the MPS was introduced into the montmorillonite due to the interactions of hydrogen bonds and ion-dipole, in addition a percentage of encapsulation efficiency of 60% was achieved.

Finally, for the kinetics of drug release in vitro the model that best adapted to the data obtained from the release in simulated gastric fluid (SGF) was the Korsmeyer-Peppas model and for simulated intestinal fluid (SIF) was the first order.


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Author Biographies

Laura Marcela Pérez Niño, Universidad Industrial de Santander

Universidad Industrial de Santander, Sede Bucaramanga, Escuela de Química, Grupo de Investigación en bioquímica y microbiología GIBIM, 680002 Bucaramanga, Colombia.

Angelica María Candela Soto, Universidad Santo Tomás

Universidad Santo Tomás, Sede Bucaramanga, Facultad de Química Ambiental, Grupo de Investigación en Nuevos Materiales y Energías Alternativas GIMNEA, Carrera 27 # 180–395, Floridablanca, Colombia.

Hernando Alberto Camargo García, Servicio Geológico Colombiano

Servicio Geológico Colombiano, Grupo de investigación de materiales de interés geológico y geotécnico, 111321 Bogotá, Colombia


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How to Cite
Pérez Niño, L., Candela Soto, A., & Camargo García, H. (2022). Controlled release of Metoprolol Succinate from the organo-mineral complex Metoprolol Succinate-Montmorillonite. ITECKNE, 19(1).
Accepted for Publication